Cardiomyocyte-derived GPX4 stabilizes BNIP3 to facilitate mitophagy and mitigate myocardial ischemia/reperfusion injury
Ontology highlight
ABSTRACT: To elucidate the molecular mechanisms by which GPX4 regulates mitochondrial function, we overexpressed GPX4 in cardiomyocytes and subjected them to hypoxia-reoxygenation (H/R) modeling. Co-immunoprecipitation (Co-IP) coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) was employed to identify potential partners of GPX4.
ORGANISM(S): Mus Musculus
SUBMITTER:
Bozhi Ye
PROVIDER: PXD072382 | iProX | Mon Dec 22 00:00:00 GMT 2025
REPOSITORIES: iProX
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