Maternal immune activation perturbs intestinal niche through microbial glycerophospholipids and drives offspring behavioral abnormalities

ABSTRACT: Using a mouse MIA model induced by prenatal exposure to Toxoplasma gondii soluble tachyzoite antigen (STAg), we reveal that maternal gut dysbiosis, characterized by increased Firmicutes and Actinobacteria, drives offspring behavioral deficits. This dysbiosis disrupts intestinal barrier integrity and induces metabolic and inflammatory dysregulation, characterized by elevated M1 macrophages and IL-6, alongside a pronounced accumulation of the glycerophospholipid. metabolite

ORGANISM(S): Mus Musculus

SUBMITTER: Zhipeng Xu  

PROVIDER: PXD075246 | iProX | Wed Mar 04 00:00:00 GMT 2026

REPOSITORIES: iProX