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Proteomic analysis of extracellular vesicles from inflammatory fibroblasts in colorectal cancer lung metastasis

ABSTRACT: Pulmonary metastasis is a major cause of mortality in colorectal cancer (CRC), and the tumor microenvironment plays a critical role in metastatic progression. In particular, inflammatory fibroblasts have been implicated in shaping the metastatic niche; however, the molecular characteristics of their extracellular vesicles (EVs) remain incompletely understood. In this study, we performed LC-MS/MS-based proteomic analysis of EVs derived from IL-1β–stimulated MRC-5 lung fibroblasts. EVs were isolated from conditioned media of MRC-5 cells with or without IL-1β treatment and subjected to comparative proteomic profiling. This dataset provides a resource for characterizing EV-associated protein alterations in inflammatory fibroblasts and supports further investigation of their potential roles in tumor-related processes in colorectal cancer lung metastasis.

ORGANISM(S): Homo Sapiens

SUBMITTER: Weipeng Wang

PROVIDER: PXD075933 | iProX | Fri Mar 20 00:00:00 GMT 2026

REPOSITORIES: iProX

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