Genetic code expansion enables site-specific acetylation to reprogram Lunasin toward BRD4 targeting

ABSTRACT: Lunasin is a plant-derived peptide with moderate anticancer activity but has limited potency and undefined molecular targets. To enhance its functional properties, we developed a site-specifically acetylated variant (Lunasin-K29ac) via genetic code expansion. To characterize the molecular interactions underlying its enhanced activity, we performed interactome profiling of a control (pET-22b-CBD), wild-type Lunasin, and Lunasin-K29ac in HT-29 cells using His pull-down MS.

ORGANISM(S): Homo Sapiens

SUBMITTER: Nanxi Wang  

PROVIDER: PXD076719 | iProX | Tue Apr 07 00:00:00 BST 2026

REPOSITORIES: iProX