Proteomics

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Fatty Acid Metabolism Reprograms Immune Microenvironment in Retinal Artery Occlusion: Multi-Omics Analysis Highlights Immunometabolic Crosstalk


ABSTRACT: This dataset contains integrated multi-omics data from a study investigating fatty acid metabolism and immune dysregulation in retinal artery occlusion (RAO). Data include serum metabolomics profiles, peripheral blood mononuclear cell (PBMC) transcriptomics, and immune phenotyping from 66 RAO patients (34 with dyslipidemia, 32 without) and 66 cataract controls. Analytical methods applied include multivariate analyses (sPLS-DA, OPLS-DA), random forest modeling, and SHAP evaluations to identify key metabolic and immune features. The dataset highlights differential fatty acid metabolites (e.g., C22:5n-3, C22:2n-6, C22:1n-9, C20:2n-6), associated gene expression changes, and immune cell alterations (elevated neutrophils, reduced lymphocytes). The data support exploration of metabolic–immune crosstalk in RAO pathogenesis and provide resources for biomarker discovery and therapeutic target validation.

ORGANISM(S): Homo Sapiens

SUBMITTER: Ying Li  

PROVIDER: PXD077366 | iProX | Sun Apr 19 00:00:00 BST 2026

REPOSITORIES: iProX

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