Proteomics

Dataset Information

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Fatty Acid Metabolism Reprograms Immune Microenvironment in Retinal Artery Occlusion: Multi-Omics Analysis Highlights Immunometabolic Crosstalk

ABSTRACT: This dataset contains integrated multi-omics data from a study investigating fatty acid metabolism and immune dysregulation in retinal artery occlusion (RAO). Data include serum metabolomics profiles, peripheral blood mononuclear cell (PBMC) transcriptomics, and immune phenotyping from 66 RAO patients (34 with dyslipidemia, 32 without) and 66 cataract controls. Analytical methods applied include multivariate analyses (sPLS-DA, OPLS-DA), random forest modeling, and SHAP evaluations to identify key metabolic and immune features. The dataset highlights differential fatty acid metabolites (e.g., C22:5n-3, C22:2n-6, C22:1n-9, C20:2n-6), associated gene expression changes, and immune cell alterations (elevated neutrophils, reduced lymphocytes). The data support exploration of metabolic–immune crosstalk in RAO pathogenesis and provide resources for biomarker discovery and therapeutic target validation.

ORGANISM(S): Homo Sapiens

SUBMITTER: Ying Li  

PROVIDER: PXD077366 | iProX | Sun Apr 19 00:00:00 GMT+01:00 2026

REPOSITORIES: iProX

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Publications

Multiomics reveals fatty acid metabolism and immune remodeling in retinal artery occlusion.

Feng Jiaqing J   Chen Duan D   Wang Chuansen C   Zhu Runlang R   Chen Longfei L   Hu Liang L   Chen Ting T   Li Ying Y   Xiao Xuan X  

iScience 20260617 7

Retinal artery occlusion (RAO), an acute ocular ischemic stroke, is critically linked to cardiovascular and metabolic dysfunction. To elucidate the interplay between lipid metabolism and immune regulation in RAO, we performed an integrated analysis using serum metabolomics, PBMC transcriptomics, and machine learning in 66 patients with RAO and 66 cataract controls. We identified systemic disruptions in fatty acid metabolism, notably elevated levels of long-chain fatty acids (C22:5<i>n</i>-3, C22  ...[more]

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