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Cleavage sites of SQLE and SREBP2 proteins in Eospalax baileyi

ABSTRACT: Experimentally validated cleavage sites of SQLE and SREBP2 proteins in plateau zokor (Eospalax baileyi)

ORGANISM(S): Eospalax Fontanierii Baileyi

SUBMITTER: Bangwei Deng

PROVIDER: PXD077704 | iProX | Tue Apr 28 00:00:00 GMT+01:00 2026

REPOSITORIES: iProX

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Low temperature rather than hypoxia drives cholesterol synthesis and oxygen consumption in plateau zokors.

Hu Qingfei Q Wei Linna L An Zhifang Z Wang Yaxuan Y Zhang Tongzuo T Wei Dengbang D

iScience 20260611 7

Subterranean burrows of plateau zokors (<i>Eospalax baileyi</i>) on the Qinghai-Tibet Plateau become significantly colder and more hypoxic with increasing altitude. Because cholesterol biosynthesis is highly oxygen-intensive, it is typically inhibited by hypoxia. Here, our findings revealed that with increasing altitude, the expression and activation of SREBP2, alongside FDFT1 and SQLE expression, were significantly upregulated in the liver. Furthermore, the incomplete degradation of SQLE produc ...[more]

PMID: 42325567

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