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Mechanical Pressure-Induced Proteome Remodeling in Corneal Epithelial Cells

ABSTRACT: Mechanical pressure can substantially alter the mechano-microenvironment of corneal epithelial cells and activate the mechanosensitive channel Piezo1 as well as its downstream interacting proteins. In this study, we will perform immunoprecipitation using an anti-Piezo1 antibody, coupled with mass spectrometry analysis (IP-MS), to systematically identify the differential interactome of Piezo1 in corneal epithelial cells under pressure stimulation, with the aim of revealing the key molecular mechanisms underlying mechanotransduction.

ORGANISM(S): Homo Sapiens

SUBMITTER: Jing Hong

PROVIDER: PXD080297 | iProX | Sat Jun 27 00:00:00 BST 2026

REPOSITORIES: iProX

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