Schizophrenia brain proteomic analysis
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Sumio Ohtsuki
PROVIDER: PXD008227 | JPOST Repository | Mon Jan 01 00:00:00 GMT 2018
REPOSITORIES: jPOST
Publications
Downregulation of GNA13-ERK network in prefrontal cortex of schizophrenia brain identified by combined focused and targeted quantitative proteomics.
Hirayama-Kurogi Mio M Takizawa Yohei Y Kunii Yasuto Y Matsumoto Junya J Wada Akira A Hino Mizuki M Akatsu Hiroyasu H Hashizume Yoshio Y Yamamoto Sakon S Kondo Takeshi T Ito Shingo S Tachikawa Masanori M Niwa Shin-Ichi SI Yabe Hirooki H Terasaki Tetsuya T Setou Mitsutoshi M Ohtsuki Sumio S
Journal of proteomics 20170216
Schizophrenia is a disabling mental illness associated with dysfunction of the prefrontal cortex, which affects cognition and emotion. The purpose of the present study was to identify altered molecular networks in the prefrontal cortex of schizophrenia patients by comparing protein expression levels in autopsied brains of patients and controls, using a combination of targeted and focused quantitative proteomics. We selected 125 molecules possibly related to schizophrenia for quantification by kn ...[more]
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