Widespread protein histidine phosphorylation in bacteria

ABSTRACT: For decades, extreme difficulties in analyzing histidine phosphorylation have limited the study of phosphohistidine signaling. Here we report a method revealing widespread and abundant protein histidine phosphorylation in E. coli. Our new approach generated the largest E. coli phosphoproteome dataset to date, of which a remarkable high percentage (~10%) are phosphohistidine sites. This resource enables a major step forward towards a better understanding of the biological function of histidine phosphorylation.

ORGANISM(S): Escherichia Coli

SUBMITTER: Albert J.R. Heck 

PROVIDER: PXD008369 | JPOST Repository | Thu Dec 07 00:00:00 GMT 2017

REPOSITORIES: jPOST