Dataset Information
Osterix propionylated peptide identification
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus (mouse)
SUBMITTER: Norie Araki
PROVIDER: PXD009147 | JPOST Repository | Mon Nov 05 00:00:00 GMT 2018
REPOSITORIES: jPOST
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| File%20relationship.xlsx | Xlsx | |||
| Inclusion_list_OSX_NAM_Prop.msf | Msf | |||
| Inclusion_list_OSX_NAM_Prop.pdResult | Other | |||
| Inclusion_list_OSX_NAM_Prop.raw | Raw | |||
| OSX_NAM_Prop.msf | Msf |
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Publications
SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix.
Nature communications 20180719 1
SP7/Osterix (OSX) is a master regulatory transcription factor that activates a variety of genes during differentiation of osteoblasts. However, the influence of post-translational modifications on the regulation of its transactivation activity is largely unknown. Here, we report that sirtuins, which are NAD(+)-dependent deacylases, regulate lysine deacylation-mediated transactivation of OSX. Germline Sirt7 knockout mice develop severe osteopenia characterized by decreased bone formation and an i ...[more]
