Dataset Information
Mouse Heart FLAG-Fam64a immunoprecipitation
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus (mouse)
SUBMITTER: Ken Hashimoto
PROVIDER: PXD020570 | JPOST Repository | Thu Apr 28 00:00:00 BST 2022
REPOSITORIES: jPOST
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SN190286_WT_90mim_2.raw | Raw | |||
| SN190286_WT_F047295.mgf | Mgf | |||
| SN190286_WT_F047295.mztab | Mztab | |||
| SN190287_TG_90min_2.raw | Raw | |||
| SN190287_TG_F047294.mgf | Mgf |
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Publications
Postnatal expression of cell cycle promoter Fam64a causes heart dysfunction by inhibiting cardiomyocyte differentiation through repression of Klf15.
iScience 20220430 5
Introduction of fetal cell cycle genes into damaged adult hearts has emerged as a promising strategy for stimulating proliferation and regeneration of postmitotic adult cardiomyocytes. We have recently identified Fam64a as a fetal-specific cell cycle promoter in cardiomyocytes. Here, we analyzed transgenic mice maintaining cardiomyocyte-specific postnatal expression of Fam64a when endogenous expression was abolished. Despite an enhancement of cardiomyocyte proliferation, these mice showed impair ...[more]
