Periodontal pathogen induces entero-hepatic metabolic derangements in type 2 diabetic mouse model

ABSTRACT: This is the first report of the metabolic and metaproteomic integrated changes in the gut and liver by the swallowed periodontopathogen. Periodontal disease pathogen Porphyromonas gingivalis are observed in faeces as peptides level in proteomic analysis and make changes in bowel microbial composition in db/db mouse. Orally Periodontal disease pathogen throwing as experimental periodontal disease model make gluconeogenesis in db/db mouse liver and hyperglycemia. Multi-omics analysis reveal Pg decreasing in energy metabolism and glucagon store in db/db mouse liver. These findings suggest that periodontal treatment improving oral microbiota can make diabetic hyperglycemia ameliorate in liver and support these diabetes treatments credibly.

ORGANISM(S): Cellular Organisms

SUBMITTER: Shinya Murakami 

PROVIDER: PXD021851 | JPOST Repository | Tue Sep 21 00:00:00 BST 2021

REPOSITORIES: jPOST