Dataset Information

SOX11 IP-MS data from Granta and Jeko cell lines in biological triplicates and IgG controls

ABSTRACT: SOX11 IP-MS data from Granta and Jeko cell lines in biological triplicates and IgG controls

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Janne Lehtö

PROVIDER: PXD030976 | JPOST Repository | Thu Jun 27 00:00:00 BST 2024

REPOSITORIES: jPOST

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			Action	DRS
	HJMLBS1_SOX11-IP_3h_3of10_A-SOX11-R1.raw	Raw
	HJMLBS1_SOX11-IP_90min_3of10_A-SOX11-R1.raw	Raw
	HJMLBS2_SOX11-IP_3h_3of10_A-SOX11-R2.raw	Raw
	HJMLBS2_SOX11-IP_90min_3of10_A-SOX11-R2.raw	Raw
	HJMLBS3_SOX11-IP_3h_3of10_A-SOX11-R3.raw	Raw

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Project description:BACKGROUND: Novel biomarkers are urgently needed to distinguish between benign and malignant thyroid nodules and detect thyroid cancer in the early stage. The associations between serum IgG N-glycosylation and thyroid cancer risk have been revealed. We aimed to explore the potential of IgG N-glycan traits as biomarkers in the differential diagnosis of thyroid cancer.METHODS: Plasma IgG N-glycome analysis was applied to a discovery cohort followed by independent validation. IgG N-glycan profiles were obtained using a robust quantitative strategy based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. IgG N-glycans were relatively quantified, and classification performance was evaluated based on directly detected and derived glycan traits.RESULTS: Four directly detected glycans were significantly changed in thyroid cancer patients compared to that in non-cancer controls. Derived glycan traits and a classification glycol-panel were generated based on the directly detected glycan traits. In the discovery cohort, derived trait BN (bisecting type neutral N-glycans) and the glyco-panel showed potential in distinguishing between thyroid cancer and non-cancer controls with AUCs of 0.920 and 0.917, respectively. The diagnostic potential was further validated. Derived trait BN and the glycol-panel displayed “accurate” performance (AUC>0.8) in discriminating thyroid cancer from benign thyroid nodules and healthy controls in the validation cohort. Meanwhile, derived trait BN and the glycol-panel also showed diagnostic potential in detecting early-stage thyroid cancer.CONCLUSIONS: IgG N-glycome analysis revealed N-glycomic differences that allow classification of thyroid cancer from non-cancer controls. Our results suggested that derived trait BN and the classification glyco-panel rather than single N-glycans may serve as candidate biomarkers for further validation.

Dataset Information

SOX11 IP-MS data from Granta and Jeko cell lines in biological triplicates and IgG controls

Dataset's files

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