Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Ashok R. Venkitaraman
PROVIDER: PXD031725 | JPOST Repository | Fri Feb 17 00:00:00 GMT 2023
REPOSITORIES: jPOST
Ho Teresa Lai Fong TLF Lee May Yin MY Goh Hui Chin HC Ng Germaine Yi Ning GYN Lee Jane Jia Hui JJH Kannan Srinivasaraghavan S Lim Yan Ting YT Zhao Tianyun T Lim Edwin Kok Hao EKH Phua Cheryl Zi Jin CZJ Lee Yi Fei YF Lim Rebecca Yi Xuan RYX Ng Perry Jun Hao PJH Yuan Ju J Chan Dedrick Kok Hong DKH Lieske Bettina B Chong Choon Seng CS Lee Kuok Chung KC Lum Jeffrey J Cheong Wai Kit WK Yeoh Khay Guan KG Tan Ker Kan KK Sobota Radoslaw M RM Verma Chandra S CS Lane David P DP Tam Wai Leong WL Venkitaraman Ashok R AR
Nature communications 20230328 1
Mis-sense mutations affecting TP53 promote carcinogenesis both by inactivating tumor suppression, and by conferring pro-carcinogenic activities. We report here that p53 DNA-binding domain (DBD) and transactivation domain (TAD) mis-sense mutants unexpectedly activate pro-carcinogenic epidermal growth factor receptor (EGFR) signaling via distinct, previously unrecognized molecular mechanisms. DBD- and TAD-specific TP53 mutants exhibited different cellular localization and induced distinct gene exp ...[more]