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Phosphoproteomic analysis of neonatal mouse heart

ABSTRACT: Benzyl isothiocyanate (BITC SIGMA 252492) was dissolved in 10% dimethyl sulfoxide (DMSO WAKO 043-29355)/PBS (nacalai 27575-31), and 20 mg/kg/day of BITC was administered to neonatal mice from P0 to P6 by subcutaneous (s. c.) injection.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Wataru Kimura

PROVIDER: PXD031900 | JPOST Repository | Thu May 08 00:00:00 BST 2025

REPOSITORIES: jPOST

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			Action	DRS
	SN210919_D1_F1_HCD_8ul.raw	Raw
	SN210919_D1_F2_HCD_8ul.raw	Raw
	SN210919_D1_F3_HCD_8ul.raw	Raw
	SN210919_D1_F4_HCD_8ul.raw	Raw
	SN210919_D1_FT_HCD_8ul.raw	Raw

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Publications

Benzyl isothiocyanate induces heart regeneration.

Sakaguchi Akane A Kawasaki Miwa M Saito Yuichi Y Murata Kozue K Masumoto Hidetoshi H Kimura Wataru W

iScience 20250522 7

Mammalian cardiomyocytes are arrested from the cell cycle shortly after birth, and therefore mammals lose the ability to regenerate injured myocardium for the rest of their lives. Pharmacological induction of cardiomyocyte proliferation has gained a lot of interest in recent years, as researchers strive to achieve heart tissue regeneration. Here, we show that a small chemical, benzyl isothiocyanate (BITC), induced cardiomyocyte proliferation through activation of the mitogen-activated protein ki ...[more]

PMID: 40585362

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