Dataset Information

Chronic high glucose condition reduced expressions of intercellular adhesion molecules and increased intercellular hyperpermeability in periodontal epithelium.

ABSTRACT: There is a close relationship between hyperglycemia in diabetes and progression of periodontal disease. This study aims to investigate the effect of hyperglycemia on the barrier function of gingival epithelial cells as a cause of hyperglycemia-exacerbated periodontitis in diabetes mellitus. Abnormal expressions of adhesion molecules in gingival epithelium in diabetes were compared between db⁄db and control mice.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Yoichiro Kashiwagi

PROVIDER: PXD035613 | JPOST Repository | Sat Jul 29 00:00:00 BST 2023

REPOSITORIES: jPOST

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			Action	DRS
	200904RY_241_258_TMT_SCX_Fr1.maxq.txt	Txt
	200904RY_241_258_TMT_SCX_Fr1.raw	Raw
	200904RY_241_258_TMT_SCX_Fr2.maxq.txt	Txt
	200904RY_241_258_TMT_SCX_Fr2.raw	Raw
	200904RY_241_258_TMT_SCX_Fr3.maxq.txt	Txt

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Chronic hyperglycemia reduces the expression of intercellular adhesion molecules and increases intercellular hyperpermeability in the periodontal epithelium.

Narukawa Yuki Y Sugiyama Naoyuki N Miura Jiro J Yamashita Rentaro R Tominaga Shotaro S Izumi Yoshihiro Y Bamba Takeshi T Ishihama Yasushi Y Kashiwagi Yoichiro Y Murakami Shinya S

Journal of periodontal research 20230523 4

<h4>Background/aims</h4>Hyperglycemia in diabetes is closely associated with periodontal disease progression. This study aimed to investigate the effect of hyperglycemia on the barrier function of gingival epithelial cells as a cause of hyperglycemia-exacerbated periodontitis in diabetes mellitus.<h4>Methods</h4>The abnormal expression of adhesion molecules in gingival epithelium in diabetes was compared between db/db and control mice. To study the effects of hyperglycemia on interepithelial cel ...[more]

PMID: 37221815

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