Chronic high glucose condition reduced expressions of intercellular adhesion molecules and increased intercellular hyperpermeability in periodontal epithelium.
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ABSTRACT:
ORGANISM(S): Mus Musculus (mouse)
SUBMITTER: Yoichiro Kashiwagi
PROVIDER: PXD035613 | JPOST Repository | Sat Jul 29 00:00:00 BST 2023
REPOSITORIES: jPOST
Publications
Chronic hyperglycemia reduces the expression of intercellular adhesion molecules and increases intercellular hyperpermeability in the periodontal epithelium.
Narukawa Yuki Y Sugiyama Naoyuki N Miura Jiro J Yamashita Rentaro R Tominaga Shotaro S Izumi Yoshihiro Y Bamba Takeshi T Ishihama Yasushi Y Kashiwagi Yoichiro Y Murakami Shinya S
Journal of periodontal research 20230523 4
<h4>Background/aims</h4>Hyperglycemia in diabetes is closely associated with periodontal disease progression. This study aimed to investigate the effect of hyperglycemia on the barrier function of gingival epithelial cells as a cause of hyperglycemia-exacerbated periodontitis in diabetes mellitus.<h4>Methods</h4>The abnormal expression of adhesion molecules in gingival epithelium in diabetes was compared between db/db and control mice. To study the effects of hyperglycemia on interepithelial cel ...[more]
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