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HFpEF model heart failure mouse treated with traditional herbal medicine Goreisan

ABSTRACT: In this project we aimed to investigate the effect of Goreisan (GRS, traditional herbal medicine) on HFpEF model heart failure mouse. HFpEF was induced by administration of high-fat diet (HFD)and N-nitro-L-arginine methyl ester (L-NAME), with or without GRS. Mouse heart proteome was analyzed with LC/MS/MS.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Masashi Hiramoto

PROVIDER: PXD049259 | JPOST Repository | Tue Sep 02 00:00:00 BST 2025

REPOSITORIES: jPOST

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			Action	DRS
	220527_01_H1_2.raw	Raw
	220527_02_H1_3.raw	Raw
	220527_03_H1_4.raw	Raw
	220527_04_H1_5.raw	Raw
	220527_05_H1_6.raw	Raw

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Publications

Goreisan attenuates cardiac hypertrophy and diastolic dysfunction in heart failure with preserved ejection fraction induced by HFD/L-NAME via regulation of ICAT-β-catenin/ERK axis.

Isayama Yoko Shojima YS Matsushima Shouji S Shinohara Keisuke K Isayama Koichi K Enzan Nobuyuki N Yamamoto Taishi T Sada Masashi M Miyake Ryo R Tsutsui Yoshitomo Y Toyohara Takayuki T Nishimura Ryohei R Ikeda Yuki Y Noda Eri E Otsuru Wataru W Tokumoto Shuya S Watanabe Masatsugu M Ikeda Masataka M Hashimoto Toru T Kinugawa Shintaro S Tsutsui Hiroyuki H Abe Kohtaro K

Hypertension research : official journal of the Japanese Society of Hypertension 20250903

Heart failure with preserved ejection fraction (HFpEF), characterized by cardiac hypertrophy and diastolic dysfunction, is increasing worldwide. Goreisan (GRS) is a traditional herbal formulation; its component attenuates cardiomyocyte hypertrophy. This study aimed to investigate the effect of GRS on the pathophysiology of HFpEF. Administration of a high fat diet (HFD, 60% fat) and N-nitro-L-arginine methylester (L-NAME, 0.5 g/L in drinking water) increased heart and lung weights in C57BL/6 mice ...[more]

PMID: 40903537

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