Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Landscape of methylation on Leishmania rRNA

ABSTRACT: We determined the methylation landscape on rRNA of Leishmania major.

ORGANISM(S): Leishmania (leishmania) Sp.

SUBMITTER: TAOKA, Masato

PROVIDER: PXD053706 | JPOST Repository | Sun Jul 06 00:00:00 BST 2025

REPOSITORIES: jPOST

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	220113_LC220107-44_Lm_WT1_LSU-beta_T1.raw	Raw
	220113_LC220107-45_Lm_WT1_LSU-alpha_T1.raw	Raw
	220113_LC220107-46_Lm_WT1_18S_T1.raw	Raw
	231115_LC220107-42_Lm_WT1_T1.raw	Raw
	231208L_major_methylation_table_RNaseT1-fragments.xlsx	Xlsx

Items per page:

1 - 5 of 5

Similar Datasets

RNA modification of of the ribosome from the anaerobic bacteria Porphyromonas gingivalis

Project description:We determined the modification landscape on rRNA of P. gingivalis.

2025-07-24 | PXD054164 | JPOST Repository

DNA methylation landscape in AML

Project description:DNA methylation landscape in AML

| PRJNA263800 | ENA

Oocyte methylation landscape

Project description:Dynamic CpG island methylation landscape in oocytes and preimplantation embryos

| PRJEB2547 | ENA

Proteogenomic landscape of medulloblastoma subgroups [methylation]

Project description:Proteogenomic landscape of medulloblastoma subgroups [methylation]

| PRJNA413673 | ENA

The landscape of human m6A methylation

Project description:The landscape of human m6A methylation

| PRJNA506210 | ENA

The DNA methylation landscape of human melanoma

Project description:The DNA methylation landscape of human melanoma

| PRJNA291991 | ENA

Profiling of 2'-O-methylation in Leishmania major rRNA using RibOxi-seq

Project description:In this study we profiled the complete repertoire of 2'-O-methylation sites present in the rRNA and a subset of small RNAs of Leishmania major rRNA using RibOxi-seq.

2024-05-01 | GSE186878 | GEO

Domain model explains propagation dynamics and stability of K27 and K36 methylation landscape

Project description:Chromatin states must be stably maintained during cell proliferation to uphold cellular identity and genome integrity. Inheritance of histone modifications across cell division is thought to be central in this process. However, the histone modification landscape is challenged by the incorporation of new unmodified histones during each cell cycle and the principles that govern heritability remain poorly defined. Here, we take a quantitative approach and develop a reusable computational model that describes propagation of K27 and K36 methylation states. We measure combinatorial K27 and K36 methylation patterns by quantitative mass spectrometry on subsequent generations of histones in the presence and absence of enzymatic inhibition. Our modelling rejects active global demethylation and invoke the existence of 8 domains defined by distinct methylation endpoints. We find that K27me3 on pre- existing histones stimulates the rate of de novo K27me3 establishment, supporting a read-write mechanism in timely chromatin restoration. Finally, we provide a detailed, quantitative picture of the mutual antagonism between K27 and K37 methylation, and propose that this antagonism enhance the stability of epigenetic states across cell division.

2020-01-29 | PXD014807 | Pride

Effect of rRNA methylation defect on protein composition of human ribosomes

Project description:Ribosomal RNAs (rRNAs) are main effectors of mRNA decoding, peptide-bond formation and ribosome dynamics during translation. Ribose 2'-O-methylation is the most abundant rRNA chemical modification, and display a complex pattern in rRNA. We globally challenged rRNA 2'-O-Me by inhibiting the rRNA methyl-transferase fibrillarin (FBL) in human cells. Since FBL participates in rRNA processing, we wonder if FBL knockdown could alter the assembly of ribosomes.

2018-04-09 | PXD007244 | Pride