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The role of Tetraspanin7 in Adipose Tissue Remodeling

ABSTRACT: Tetraspanin7 (Tspan7) is involved in the regulation of body weight, but the detailed mechanisms remain unclear. Here, to reveal the mechanisms, human adipose-derived stem cells were transduced with sh-Tspan7, control-sh, Tspan7-Flag, and Myc-Tspan7 using lentivirus. Following the transduction, adipogenic differentiation was induced and the differentiated adipocytes were characterized by LC-MS/MS.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Shino Nemoto

PROVIDER: PXD059268 | JPOST Repository | Thu Jan 30 00:00:00 GMT 2025

REPOSITORIES: jPOST

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			Action	DRS
	001_Nemoto01_250ng_T120SW_B2o5.wiff	Wiff
	001_Nemoto01_250ng_T120SW_B2o5.wiff.scan	Wiff
	001_Nemoto01_250ng_T120_B2o5.wiff	Wiff
	001_Nemoto01_250ng_T120_B2o5.wiff.scan	Wiff
	002_Nemoto02_250ng_T120SW_B2o5.wiff	Wiff

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Tetraspanin7 in adipose tissue remodeling and its impact on metabolic health.

Nemoto Shino S Uchida Kazuyo K Kubota Tetsuya T Nakayama Manabu M Han Yong-Woon YW Koyasu Shigeo S Ohno Hiroshi H

Molecular metabolism 20250512

<h4>Objective</h4>We previously identified tetraspanin 7 (Tspan7) as a candidate gene influencing body weight in an obesity-related gene screening study. However, the mechanisms underlying its involvement in body weight regulation remained unclear. This study aims to investigate the role of TSPAN7 from a metabolic perspective.<h4>Methods</h4>We utilized genetically modified mice, including adipose tissue-specific Tspan7-knockout and Tspan7-overexpressing models, as well as human adipose-derived ...[more]

PMID: 40368161

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