Dataset Information
Mitochondrial acetylome for eMAT substrates
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Yoichi Shinkai
PROVIDER: PXD061245 | JPOST Repository | Fri Jul 18 00:00:00 BST 2025
REPOSITORIES: jPOST
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 240624_EC_HCD_IT_FAIMS_023_Shimazu_01_1_2nd.raw | Raw | |||
| 240624_EC_HCD_IT_FAIMS_023_Shimazu_02_2_2nd.raw | Raw | |||
| 240624_EC_HCD_IT_FAIMS_023_Shimazu_03_3_2nd.raw | Raw | |||
| Table_S1.xlsx | Xlsx |
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Publications
Mitochondrial hyper-acetylation induced by an engineered acetyltransferase promotes cellular senescence.
iScience 20250729 9
Protein acetylation plays crucial roles in diverse biological functions, including mitochondrial metabolism. Although SIRT3 catalyzes the removal of acetyl groups in mitochondria, the addition of the acetyl groups is thought to be primarily controlled in an enzyme-independent manner due to the absence of potent acetyltransferases. In this study, we developed an engineered mitochondria-localized acetyltransferase, named engineered mitochondrial acetyltransferase (eMAT). eMAT localized in the mito ...[more]
