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Mitochondria SILAC-LC-MS/MS for eMAT substrates

ABSTRACT: Substrates screening for eMAT in HEK293T mitochondria.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Yoichi Shinkai

PROVIDER: PXD061246 | JPOST Repository | Fri Jul 18 00:00:00 GMT+01:00 2025

REPOSITORIES: jPOST

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			Action	DRS
	240513_EC_HCD_IT_SILAC_FAIMS_015_01_Shimazu_A_2nd.raw	Raw
	240513_EC_HCD_IT_SILAC_FAIMS_015_02_Shimazu_B_2nd.raw	Raw
	240513_EC_HCD_IT_SILAC_FAIMS_015_03_Shimazu_C_2nd.raw	Raw
	Table_S2.xlsx	Xlsx

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Publications

Mitochondrial hyper-acetylation induced by an engineered acetyltransferase promotes cellular senescence.

Shimazu Tadahiro T Kataoka Ayane A Suzuki Takehiro T Dohmae Naoshi N Shinkai Yoichi Y

iScience 20250729 9

Protein acetylation plays crucial roles in diverse biological functions, including mitochondrial metabolism. Although SIRT3 catalyzes the removal of acetyl groups in mitochondria, the addition of the acetyl groups is thought to be primarily controlled in an enzyme-independent manner due to the absence of potent acetyltransferases. In this study, we developed an engineered mitochondria-localized acetyltransferase, named engineered mitochondrial acetyltransferase (eMAT). eMAT localized in the mito ...[more]

PMID: 40822901

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