Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Global proteomics and metabolic data for CD36-mediated endocytosis of proteolysis-targeting chimeras

ABSTRACT: Global proteomics and metabolic data for CD36-mediated endocytosis of proteolysis-targeting chimeras are deposited here.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Hong-yu Li

PROVIDER: PXD062797 | JPOST Repository | Thu Apr 10 00:00:00 BST 2025

REPOSITORIES: jPOST

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	Data_S1_Global_proteomic_analysis_raw_data.xlsx	Xlsx
	Global_proteomics_033949_QinZ_20241126_02_DIA.sne	Other
	Global_proteomics_QinZ_20241126_02_DIA_raw.zip	Other
	Table_S4_Metabolomic_assay_raw_data.xlsx	Xlsx

Items per page:

1 - 4 of 4

Similar Datasets

Global proteomics and metabolic data for CD36-mediated endocytosis of proteolysis-targeting chimeras

Project description:Global proteomics and metabolic data for CD36-mediated endocytosis of proteolysis-targeting chimeras has been deposited here.

2025-04-09 | PXD062747 | JPOST Repository

Expression data of miR-95 transfection in MCF-7 cells compared with scramble control

Project description:We identified miR-95 in a screen for miRNAs which functionally affect autophagic flux in MCF-7 cells. We over expressed miR-95 or a scramble control and isolated total RNA for microarray analysis. We identified several biological pathways and targets regulated by miR-95 including genes related to endocytosis, ubiquitin mediated proteolysis and lysosomal function.

2014-12-30 | GSE58142 | GEO

YY1-mediated targeting of MSL/MOF

Project description:YY1-mediated targeting of MSL/MOF

| PRJNA1012719 | ENA

Targeting NAT10 inhibits hepatocarcinogenesis via ac4C-mediated

Project description:Targeting NAT10 inhibits hepatocarcinogenesis via ac4C-mediated

| PRJNA1262378 | ENA

Targeting CDK12-mediated transcription regulation in anaplastic thyroid carcinoma

Project description:Targeting CDK12-mediated transcription regulation in anaplastic thyroid carcinoma

| PRJNA566339 | ENA

Targeting the ADPKD methylome using nanoparticle-mediated combination therapy

Project description:Targeting the ADPKD methylome using nanoparticle-mediated combination therapy

| PRJNA834131 | ENA

Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling

Project description:Histone methyltransferase Setd2 mitigates T cell-mediated autoimmunity by targeting Lpcat4-mediated phospholipid remodeling

| PRJNA987673 | ENA

Expression data from murine wildtype and Sh3gl1-/- B cells

Project description:We show that antigen internalization depends both on constitutive, clathrin-mediated endocytosis and on antigen-induced, clathrin-independent endocytosis mediated by endophilin A2. Although endophilin A2-mediated endocytosis is dispensable for antigen presentation, it is selectively required for metabolic support of B cell proliferation, in part through regulation of iron uptake. Consequently, endophilin A2 deficient mice show defects in GC B cell responses and production of high-affinity IgG. The requirement for endophilin A2 highlights a unique importance of clathrin-independent intracellular trafficking in GC B cell clonal expansion and antibody responses

2021-07-19 | GSE172295 | GEO

An NSD3-targeting PROTAC (Proteolysis Targeting Chimeric) suppresses the NSD3 and cMyc oncogenic nodes in cancer cells

Project description:An NSD3-targeting PROTAC (Proteolysis Targeting Chimeric) suppresses the NSD3 and cMyc oncogenic nodes in cancer cells

| PRJNA664766 | ENA

Downregulation of RING ligase praja2 boosts receptor tyrosine kinases in kidney cancer

Project description:Clear cell renal cell carcinoma (ccRCC) is the most common variant of kidney cancer in the adult population. Late diagnosis, resistance to therapeutics and recurrence of metastatic lesions account for the highest mortality rate among kidney cancer patients. Identifying novel biomarkers for early cancer detection and the mechanisms underlying ccRCC growth and progression will provide clues to treat this aggressive malignant tumor. Here, we report that the RING ligase praja2 is a novel component of the endocytic system that supports clathrin-mediated receptor endocytosis. At molecular level, we identify the adaptor protein AP2 as a binding partner and substrate of praja2. Functionally, we demonstrate that praja2 is required for AP2-mediated receptor endocytosis and clearance. Downregulation of praja2 in RCC cells and tissues is associated with a marked upregulation of membrane receptors, as EGFR, VEGFR and TfR. A negative feedback loop links EGF signaling to proteolysis of praja2 and sustains downstream mitogenic and proliferative pathways. Restoring praja2 expression in RCC cells remarkably decreases EGFR levels, rewires cancer cell metabolism and inhibits RCC growth and metastatic diffusion. In praja2 knockout mice, upregulation of RTKs levels associates with profound histopathological renal alterations. Our findings identify praja2 as a component of the endocytic pathway that supports receptor endocytosis and clearance. Downregulation of praja2 in RCC cells, thus, sustains RTK signaling and promotes kidney cancer growth and diffusion.

2023-08-13 | E-MTAB-11900 | biostudies-arrayexpress