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Proteomic profiling of in vitro knockdown of SMARCA4 in Medulloblastoma

ABSTRACT: SMARCA4 mutations are common in Medulloblastoma but not much is understood about its pathobiology. In this study we prepared SMARCA4 knockdown models using a Group 3 medulloblastoma cell line called HDMB03 and investigated the proteomic changes. We performed both DDA and DIA analyses and found that DIA performed better for our study. Our findings highlight that SMARCA4 loss disrupts proliferative and chromatin-regulatory networks while inducing metabolic reprogramming in vitro Group 3 MB.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Prof. Sanjeeva Srivastava

PROVIDER: PXD070640 | JPOST Repository | Wed Mar 25 00:00:00 GMT 2026

REPOSITORIES: jPOST

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			Action	DRS
	16082023_MG_C1.raw	Raw
	16082023_MG_C3.raw	Raw
	16082023_MG_O1_1.raw	Raw
	16082023_MG_O1_3.raw	Raw
	16082023_MG_O2_1.raw	Raw

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