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CFTR interactome

ABSTRACT: The uploaded files are the RAW files used to generate the CFTR interactome dataset. The raw data were searched with ProLuCID against the human IPI database version 3.23 and search results were filtered with DTASelect 2.1.

INSTRUMENT(S): LTQ Orbitrap XL, LTQ, LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: John R Yates

PROVIDER: MSV000079235 | MassIVE | Thu Aug 13 12:50:00 BST 2015

SECONDARY ACCESSION(S): PXD002722

REPOSITORIES: MassIVE

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Publications

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

Pankow Sandra S Bamberger Casimir C Calzolari Diego D Martínez-Bartolomé Salvador S Lavallée-Adam Mathieu M Balch William E WE Yates John R JR

Nature 20151130 7583

Deletion of phenylalanine 508 of the cystic fibrosis transmembrane conductance regulator (∆F508 CFTR) is the major cause of cystic fibrosis, one of the most common inherited childhood diseases. The mutated CFTR anion channel is not fully glycosylated and shows minimal activity in bronchial epithelial cells of patients with cystic fibrosis. Low temperature or inhibition of histone deacetylases can partly rescue ∆F508 CFTR cellular processing defects and function. A favourable change of ∆F508 CFTR ...[more]

PMID: 26618866

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