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Proteomic characterization of MEIOC interactants: part 2

ABSTRACT: Identification of MEIOC interactants by immunoprecipitation and shotgun proteomics

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr Jean Armengaud

PROVIDER: MSV000079991 | MassIVE | Fri Jul 22 16:06:00 BST 2016

SECONDARY ACCESSION(S): PXD003200

REPOSITORIES: MassIVE

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Publications

Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts.

Abby Emilie E Tourpin Sophie S Ribeiro Jonathan J Daniel Katrin K Messiaen Sébastien S Moison Delphine D Guerquin Justine J Gaillard Jean-Charles JC Armengaud Jean J Langa Francina F Toth Attila A Martini Emmanuelle E Livera Gabriel G

Nature communications 20160108

Sexual reproduction is crucially dependent on meiosis, a conserved, specialized cell division programme that is essential for the production of haploid gametes. Here we demonstrate that fertility and the implementation of the meiotic programme require a previously uncharacterized meiosis-specific protein, MEIOC. Meioc invalidation in mice induces early and pleiotropic meiotic defects in males and females. MEIOC prevents meiotic transcript degradation and interacts with an RNA helicase that binds ...[more]

PMID: 26742488

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