Proteomics

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C. elegans SUP-46, an HNRNPM family RNA-binding protein that prevents paternally-mediated epigenetic sterility


ABSTRACT: BioID screening of HNRNPM, MYEF2 in HEK293 cell line.

INSTRUMENT(S): LTQ Orbitrap Velos, LTQ Orbitrap Elite

SUBMITTER: Anne-Claude Gingras  

PROVIDER: MSV000080631 | MassIVE | Tue Mar 14 15:33:00 GMT 2017

SECONDARY ACCESSION(S): PXD006094

REPOSITORIES: MassIVE

Dataset's files

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Action DRS
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params.xml Xml
15288_802_BirA_BR5_TR1_WD_01132014_Elite_1P_AS1.mzTab Mztab
15358_861_BirAFLAG_BR4_TR1_WD_01232014_Elite_1P_AS1.mzTab Mztab
17079_1095_BirAFLAG_BR7_TR1_WD_4022014_Elite_1P_AS1.mzTab Mztab
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Publications

C. elegans SUP-46, an HNRNPM family RNA-binding protein that prevents paternally-mediated epigenetic sterility.

Johnston Wendy L WL   Krizus Aldis A   Ramani Arun K AK   Dunham Wade W   Youn Ji Young JY   Fraser Andrew G AG   Gingras Anne-Claude AC   Dennis James W JW  

BMC biology 20170717 1


<h4>Background</h4>In addition to DNA, gametes contribute epigenetic information in the form of histones and non-coding RNA. Epigenetic programs often respond to stressful environmental conditions and provide a heritable history of ancestral stress that allows for adaptation and propagation of the species. In the nematode C. elegans, defective epigenetic transmission often manifests as progressive germline mortality. We previously isolated sup-46 in a screen for suppressors of the hexosamine pat  ...[more]

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