Proteomics

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Aortic Aneurysm iTRAQ HiRIEF proteomics

ABSTRACT: Conducted proteomics on samples from patients with aortic aneurysm and from non-dilated controls. Furthermore, we investigated both patients with bicuspid aortic valves (BAV) and also the more normal tricuspid aortic valves (TAV). The aim was to elucidate the molecular mechanisms behind the higher propensity of BAV patients to develop aorta dilation and consequent aortic aneurysm.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Janne Lehti�  

PROVIDER: MSV000080837 | MassIVE | Fri Mar 31 18:53:00 BST 2017

SECONDARY ACCESSION(S): PXD003702

REPOSITORIES: MassIVE

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Publications

Mesenchymal state of intimal cells may explain higher propensity to ascending aortic aneurysm in bicuspid aortic valves.

Maleki Shohreh S   Kjellqvist Sanela S   Paloschi Valentina V   Magné Joelle J   Branca Rui Miguel Mamede RM   Du Lei L   Hultenby Kjell K   Petrini Johan J   Fuxe Jonas J   Lehtiö Janne J   Franco-Cereceda Anders A   Eriksson Per P   Björck Hanna M HM  

Scientific reports 20161025

Individuals with a bicuspid aortic valve (BAV) are at significantly higher risk of developing aortic complications than individuals with tricuspid aortic valves (TAV) and defective signaling during the embryonic development and/or life time exposure to abnormal hemodynamic have been proposed as underlying factors. However, an explanation for the molecular mechanisms of aortopathy in BAV has not yet been provided. We combined proteomics, RNA analyses, immunohistochemistry, and electron microscopy  ...[more]

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