Proteomics

Dataset Information

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Cytosolic proteome of Staphylococcus aureus HG001 post internalization in bronchial epithelial cells - S. aureus dataset


ABSTRACT: The data set consists of 32 S. aureus cytosolic samples that were collected by GFP supported cell sorting during infection in lung epithelial cells. The data include 8 time points (2.5 h, 6.5 h , 24 h, 48 h, 72 h, and 96 h post infection plus exponential and non-adherent control) that were collected out of four biological replicates. DIA data are provided. The respective spectral library was already published (Michalik et al., 2017, Sci Rep. doi: 10.1038/s41598-017-10059-w.

INSTRUMENT(S): Q Exactive

SUBMITTER: Prof. Dr. Uwe Voelker  

PROVIDER: MSV000082920 | MassIVE | Fri Sep 07 00:32:00 BST 2018

SECONDARY ACCESSION(S): PXD011028

REPOSITORIES: MassIVE

Dataset's files

Source:
Action DRS
Other
params.xml Xml
statistics.tsv Tabular
Protocol_S_aureus.docx Other
160217_QEp_LP_1D_R2.raw Raw
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Publications

Metabolic Cross-talk Between Human Bronchial Epithelial Cells and Internalized <i>Staphylococcus aureus</i> as a Driver for Infection.

Palma Medina Laura M LM   Becker Ann-Kristin AK   Michalik Stephan S   Yedavally Harita H   Raineri Elisa J M EJM   Hildebrandt Petra P   Gesell Salazar Manuela M   Surmann Kristin K   Pförtner Henrike H   Mekonnen Solomon A SA   Salvati Anna A   Kaderali Lars L   van Dijl Jan Maarten JM   Völker Uwe U  

Molecular & cellular proteomics : MCP 20190226 5


<i>Staphylococcus aureus</i> is infamous for causing recurrent infections of the human respiratory tract. This is a consequence of its ability to adapt to different niches, including the intracellular milieu of lung epithelial cells. To understand the dynamic interplay between epithelial cells and the intracellular pathogen, we dissected their interactions over 4 days by mass spectrometry. Additionally, we investigated the dynamics of infection through live cell imaging, immunofluorescence and e  ...[more]

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