Proteomics

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A mitochondrial proteome profile of type 2 diabetes mellitus in skeletal muscles


ABSTRACT: The goal of the project is to understand the mitochondrial proteome profiles related to T2DM. We performed comprehensive proteome profiling of mitochondria isolated from skeletal muscles in nine T2DM patients and nine control subjects with normal glucose tolerance (NGT).

INSTRUMENT(S): LTQ FT

ORGANISM(S): Homo sapiens  

SUBMITTER: Sang-Won Lee  

PROVIDER: MSV000083560 | Massive | Wed Mar 13 00:01:00 GMT 2019

SECONDARY ACCESSION(S): PXD004312

REPOSITORIES: MassIVE

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Publications


The pathogenesis of type 2 diabetes mellitus (T2DM) is closely associated with mitochondrial functions in insulin-responsive tissues. The mitochondrial proteome, compared with the mitochondrial genome, which only contains 37 genes in humans, can provide more comprehensive information for thousands of mitochondrial proteins regarding T2DM-associated mitochondrial functions. However, T2DM-associated protein signatures in insulin-responsive tissues are still unclear. Here, we performed extensive pr  ...[more]

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