A Multi-Omics Interpretable Machine Learning Model Reveals Modes of Action of Small Molecules

ABSTRACT: Cells expressing mutant huntingtin were treated in triplicate with serum-free DMEM with vehicle (Q111SST) or serum-free DMEM with one of 4 protective compounds (Cyproheptadine, Loxapine, Diacylglycerol Kinase Inhibitor II, Meclizine) for 24 hours. Wild type cells were also treated with serum-free DMEM with vehicle (Q7SST) as an additional control for 24 hours. We examined the compounds' proteomic and some phosphoproteomic effects on the cells using shotgun proteomics.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Ernest Fraenkel  

PROVIDER: MSV000084607 | MassIVE | Wed Nov 20 19:46:00 GMT 2019

REPOSITORIES: MassIVE