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Micronuclear and nuclear epiproteome profiles following diverse genotoxic stress conditions

ABSTRACT: Histone modifications profiled by mass spectrometry, in micronuclei (MN) and nuclei from HeLa cells acutely treated with DMSO, 10 Gy ionizing radiation, methyl methanesulfonate (MMS), hydroxyurea (HU), paclitaxel, or 5,6-dichloro-1-beta-ribo-furanosyl benzimidazole (DRB). MN and nuclei were purified by sucrose density gradient prior to preparation for mass spectrometry. Mass spectrometry and data preparation performed by Northwestern Proteomics Core using their Epiproteome Histone Panel.

INSTRUMENT(S): TSQ Altis

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Shane Harding

PROVIDER: MSV000089836 | MassIVE | Thu Jul 07 07:28:00 BST 2022

REPOSITORIES: MassIVE

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