Fallopian tube secreted proteins affect ovarian metabolites in high grade serous ovarian cancer
Ontology highlight
ABSTRACT:
INSTRUMENT(S): autoflex II, timsTOF fleX, Q Exactive
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090)
SUBMITTER: 
Laura M Sanchez Joanna Burdette
PROVIDER: MSV000089866 | MassIVE | Mon Jul 11 15:52:00 BST 2022
REPOSITORIES: MassIVE
Publications
Fallopian tube secreted protein affects ovarian metabolites in high grade serous ovarian cancer.
Bergsten Tova M TM Levy Sarah E SE Zink Katherine E KE Lusk Hannah J HJ Pergande Melissa R MR Cologna Stephanie M SM Burdette Joanna E JE Sanchez Laura M LM
Frontiers in cell and developmental biology 20221107
High grade serous ovarian cancer (HGSOC), the most lethal histotype of ovarian cancer, frequently arises from fallopian tube epithelial cells (FTE). Once transformed, tumorigenic FTE often migrate specifically to the ovary, completing the crucial primary metastatic step and allowing the formation of the ovarian tumors after which HGSOC was originally named. As only the fimbriated distal ends of the fallopian tube that reside in close proximity to the ovary develop precursor lesions such as serou ...[more]
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