Synphilin-1 upregulates RBL2 expression and causes a G0/G1 phase cell cycle arrest in the neurons

ABSTRACT: Synphilin-1, a major component of Lewy bodies in the brain of Parkinsons disease (PD) patients, is a cytoplasmic protein that interacts with alpha-synuclein and is suggested to have cytoprotective effects in the neuronal cells. alpha-Synuclein overexpression induced re-entry of the neuronal cells into the cell cycle, which is associated with neuronal death. However, the role of synphilin-1 in cell cycle progression remains unelucidated. Here, we aimed at investigating the role of synphilin-1 in cell cycle progression using human embryonic kidney (HEK) 293 cells, human neuroblastoma SH-SY5Y cells, and post-mortem brains of PD patients.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus <mouse, Genus> (ncbitaxon:10088)

SUBMITTER: Gwang Lee  

PROVIDER: MSV000089926 | MassIVE | Wed Jul 20 03:05:00 BST 2022

REPOSITORIES: MassIVE