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Forebrain Hindbrain histone H4 Mus musculus P25 P47

ABSTRACT: Quantitative top down analysis of histone H4 proteoforms in the mouse forebrain and hindbrain at 25 and 47 days of age.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Nicolas L. Young

PROVIDER: MSV000090249 | MassIVE |

REPOSITORIES: MassIVE

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Histone H4 proteoforms and post-translational modifications in the Mus musculus brain with quantitative comparison of ages and brain regions.

Taylor Bethany C BC Young Nicolas L NL

Analytical and bioanalytical chemistry 20230208 9

Histone proteins are essential to the regulation of the eukaryotic genome. Histone post-translational modifications (PTMs) and single-molecule combinations of these modifications (proteoforms) allow for the regulation of many DNA-templated processes, most notably transcription. Histone H4 is a part of the core histone octamer, which packages DNA into nucleosomes. Top-down proteomics allows for the inquiry of the epigenetic landscape with proteoform-level specificity. Although these approaches ar ...[more]

PMID: 36754872

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