Proteomics

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YjbH contributes to S. aureus skin pathology and immune response through Agr-mediated alpha-toxin regulation

ABSTRACT: Staphylococcus aureus is a global health threat that can cause a multitude of diseases in many different areas of the body and is the leading cause of skin infections. This bacterium can produce a variety of proteins that contribute to virulence and disease progression. These virulence factors include alpha-hemolysin (Hla), which can kill many different cell types in the human body. In this study, we identified a new protein that contributes to Hla production, YjbH. It does so by controlling the activity of the Accessory Gene Regulator (Agr), a major player in the modulation of proteins produced in the bacterium. We demonstrate that without YjbH, S. aureus cultures produce less Hla, and this is corroborated during infection. Accordingly, when YjbH is present, tissue damage is greater during infection than when it is absent. Overall, our study sheds light on the complex regulation involved in virulence factor production by S. aureus and its ability to cause a wide range of diseases.

INSTRUMENT(S): Orbitrap Ascend

ORGANISM(S): Staphylococcus Aureus Subsp. Aureus Usa300 (ncbitaxon:367830)

SUBMITTER: Jeffrey L. Bose  

PROVIDER: MSV000094753 | MassIVE | Tue May 14 08:03:00 BST 2024

SECONDARY ACCESSION(S): PXD052261

REPOSITORIES: MassIVE

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YjbH contributes to <i>Staphylococcus aureus</i> skin pathology and immune response through Agr-mediated α-toxin regulation.

McReynolds Aubrey K G AKG   Pagella Emma A EA   Ridder Miranda J MJ   Rippee Olivia O   Clark Zachary Z   Rekowski Michaella J MJ   Pritchard Michele T MT   Bose Jeffrey L JL  

Virulence 20240909 1

<i>Staphylococcus aureus</i> is the most common cause of skin and soft tissue infections (SSTIs) with Methicillin-Resistant <i>S. aureus</i> (MRSA) strains being a major contributor in both community and hospital settings. <i>S. aureus</i> relies on metabolic diversity and a large repertoire of virulence factors to cause disease. This includes α-hemolysin (Hla), an integral player in tissue damage found in various models, including SSTIs. Previously, we identified a role for the Spx adapter prot  ...[more]

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