Lysosomal protein atlas of brain cell types identifies SLC45A1-associated disease as a lysosomal disorder

ABSTRACT: We identify dozens of novel lysosomal proteins across brain cells, including those linked to disease. Notably, we found that SLC45A1, mutations in which cause a monogenic neurological disease, is a neuron-specific lysosomal protein. Here, we identify potential interaction partners of SLC45A1, but also TMEM192, a well-known lysosomal transmembrane protein.

INSTRUMENT(S): Orbitrap Exploris 480, nanoACQUITY UPLC System with 1D Technology

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Alessandro Ori  

PROVIDER: MSV000096053 | MassIVE | Wed Oct 09 08:57:00 BST 2024

SECONDARY ACCESSION(S): PXD056657

REPOSITORIES: MassIVE