Dataset Information

Effect of menstrual blood-derived mesenchymal stromal cell secretomes on macrophage polarization: therapeutic insights

ABSTRACT: Menstrual blood-derived mesenchymal stromal cells (MenSCs) are a promising alternative source of MSCs for clinical applications due to their unique advantages, including easy isolation and high proliferative capacity. They possess immunomodulatory and regenerative capabilities, interacting with immune cells like macrophages and promoting tissue repair. While MenSCs hold therapeutic potential, cell-based therapies face limitations such as low survival rates and unpredictable paracrine activity. Therefore, utilizing the MenSC-derived secretome offers a potentially more effective therapeutic strategy. This study investigates the immunomodulatory capacity of the MenSC-derived secretome on macrophage differentiation, polarization, and repolarization. Here, label-free mass spectrometry analyses were conducted to identify the key immunomodulatory proteins involved in the effects of the MenSC-derived secretome. This research provides novel insights into the MenSC secretome's impact on macrophage modulation, paving the way for developing innovative cell-free therapies for immune and inflammatory diseases.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Esther Lopez Maria Gomez-Serrano

PROVIDER: MSV000096909 | MassIVE | Wed Jan 22 06:28:00 GMT 2025

SECONDARY ACCESSION(S): PXD060067

REPOSITORIES: MassIVE

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Publications

Menstrual blood-derived mesenchymal stromal cells: impact of preconditioning on the cargo of extracellular vesicles as potential therapeutics.

de Pedro María Ángeles MÁ López Esther E González-Nuño Francisco Manuel FM Pulido María M Álvarez Verónica V Marchena Ana María AM Preußer Christian C Szymański Witold W Pogge von Strandmann Elke E Graumann Johannes J Sánchez-Margallo Francisco Miguel FM Casado Javier G JG Gómez-Serrano María M

Stem cell research & therapy 20230728 1

<h4>Background</h4>Mesenchymal stromal cells (MSCs) have been shown to exert their therapeutic effects through the secretion of broad spectrum of paracrine factors, including extracellular vesicles (EVs). Accordingly, EVs are being pursued as a promising alternative to cell-based therapies. Menstrual blood-derived stromal cells (MenSCs) are a type of MSC that, due to their immunomodulatory and regenerative properties, have emerged as an innovative source. Additionally, new strategies of cell pri ...[more]

PMID: 37507751

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