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Title: Demographic Factors Predictive of Skin Barrier Function in a Large Population-Based Study

ABSTRACT: The skin has a vital role in homeostasis, but there are limited and conflicting data on factors associated with skin barrier function. We evaluated the relationship between participant characteristics and four barrier function measures in a diverse population-based sample of 286 participants ages 32-97 in the Baltimore Longitudinal Study of Aging (BLSA), a well-characterized cohort of healthy aging. Multivariable analysis indicated older age, female sex, Black race/ethnicity, and higher BMI were associated with at least one measure of better barrier function: older age was associated with better dynamic barrier function (beta=-0.141, p=0.034) and barrier permeability (beta=-0.158, p=0.018); female participants had superior dynamic barrier function (beta=0.164, p=0.027) and increased barrier recovery (beta=-0.239, p=0.001); black participants also had better dynamic barrier function (beta=-0.200, p=0.006) and higher barrier integrity (beta=0.256, p<0.001); and higher BMI was associated with better barrier integrity (beta=0.131, p=0.033). Protein expression from tape strips analyzed by mass spectrometry among a sub-sample of 20 participants showed that protein families linked to barrier composition and insult response were higher among participants with above-median barrier function (p<0.01). Our results provide a framework for future research on epidermal barrier function and suggest additional measures are needed to differentiate age-associated barrier decline.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Katrina Abuabara

PROVIDER: MSV000097834 | MassIVE | Thu May 08 15:12:00 BST 2025

SECONDARY ACCESSION(S): PXD063780

REPOSITORIES: MassIVE

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