Proteomics

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Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12

ABSTRACT: NRF2 FLAG IP to determine intracellular interactors

INSTRUMENT(S): Q Exactive GC Orbitrap

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Michael Rape  

PROVIDER: MSV000098529 | MassIVE | Tue Jul 15 17:36:00 BST 2025

REPOSITORIES: MassIVE

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Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12.

Ingersoll Andrew J AJ   McCloud Devlon M DM   Hu Jenny Y JY   Rape Michael M  

bioRxiv : the preprint server for biology 20241125

The oxidative stress response is centered on the transcription factor NRF2 and protects cells from reactive oxygen species (ROS). While ROS inhibit the E3 ligase CUL3 <sup>KEAP1</sup> to stabilize NRF2 and elicit antioxidant gene expression, cells recovering from stress must rapidly reactivate CUL3 <sup>KEAP1</sup> to prevent reductive stress and oxeiptosis-dependent cell death. How cells restore efficient NRF2-degradation upon ROS clearance remains poorly understood. Here, we identify TRIP12, a  ...[more]

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