Dataset Information

The effect of an NAT10 inhibitor (remodelin) on inflammation-related genes in the treatment of thalamic hemorrhage based on metabolic data

ABSTRACT:

Thalamic hemorrhage is a disease caused by hemorrhage of the thalamic brain parenchyma and is accompanied by an inflammatory response during development. NAT10 has been associated with a wide range of diseases. The aim of this study was to explore the molecular mechanisms associated with the use of the NAT10 inhibitor (Remodelin) for the treatment of thalamic hemorrhage from an inflammatory perspective.

INSTRUMENT(S): Liquid Chromatography MS -

PROVIDER: MTBLS11941 | MetaboLights | 2025-11-13

REPOSITORIES: MetaboLights

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Publications

Identification and Mechanistic Studies of Key Genes in Thalamic Hemorrhage Pain by Multi-omics.

Yang Chen C Gao Ju J Li Yaqun Y Xiao Yinggang Y Huang Tianfeng T

Journal of integrative neuroscience 20250701 7

<h4>Background</h4>Thalamic hemorrhage pain (THP), a subtype of central post-stroke pain (CPSP), commonly develops following ischemic or hemorrhagic injury to the thalamus. Current therapeutic options remain inadequate due to the absence of well-defined molecular targets. This study aimed to elucidate critical genes implicated in THP pathogenesis through an integrated multi-omics approach.<h4>Methods</h4>A mouse model of THP was established and mice were divided into THP and control groups. Comp ...[more]

PMID: 40767016

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