Metagenomic and Metabolomic Analysis of Gut Microbiota's Impact on Sperm Motility in Rongchang Boars

ABSTRACT:

This study focused on the association between gut microbiota and sperm motility, with an emphasis on analyzing differential metabolites in the intestines and blood of Rongchang boars from the high sperm motility group (group H) and low sperm motility group (group L). The results revealed that eicosapentaenoic acid (EPA) was a differential metabolite commonly present in both the intestines and blood of the two groups. Comprehensive analysis indicated that alterations in gut microbiota can promote the accumulation of EPA in the intestines and blood, and EPA may exert a positive effect on sperm motility through mechanisms such as antioxidant activity and improvement of membrane fluidity. This finding provides important clues for revealing the potential mechanism by which gut microbiota regulates sperm motility through metabolites, and has certain reference value in the field of agricultural breeding.

INSTRUMENT(S): Liquid Chromatography MS - negative - reverse phase, Liquid Chromatography MS - positive - reverse phase

PROVIDER: MTBLS12712 | MetaboLights | 2025-07-14

REPOSITORIES: MetaboLights