Composite polyphenols mitigate microplastic exposure-related immune disturbances: a two-phase population trial

ABSTRACT:

As people are being widely exposed to microplastics (MPs), it is urgent to elucidate their toxicity mechanisms and identify intervention strategies to mitigate their adverse effects. This study firstly designed a two-phase population trial, comprising a pilot population (n = 151) to investigate the MP toxicity mechanisms and a 28-day randomized, double-blind, placebo-controlled trial (n = 98) evaluating the effects of an intervention with composite polyphenols (CP). By integrating a multi-omics approach with phenotype, this study found that MPs could affect specific inflammation and lipid indicators. The underlying mechanism was related to downregulated phosphatidylcholine (PC) 22:5/0:0 and stearidonic acid caused by gut microbiota disruption. CP intervention could mitigate the increase in pro-inflammatory indicators associated with high MP exposure by modulating gut microbiota and up-regulating the glycerophospholipid metabolism and arginine biosynthesis pathways. The gut microorganism Sutterella and plasma metabolite PC (22:5/0:0) may serve as potential targets for this protective action.

INSTRUMENT(S): Liquid Chromatography MS - negative - reverse phase, Liquid Chromatography MS - positive - reverse phase

PROVIDER: MTBLS12863 | MetaboLights | 2026-08-01

REPOSITORIES: MetaboLights