Measurements of fecal bile acids abundance in DSS induced UC mice model

ABSTRACT:

Background and aims: Elevation of conjugated primary bile acid—GCA in fecal samples was reported in IBD patients compared to healthy controls (nearly 10-fold), as well as in active ulcerative colitis (UC) patients relative to those in remission stages. Therefore we wanted to investigate the potential role of GCA in colitis progression. Here, we would like to know how fecal GCA abundance changes during acute UC progression in C57BL/6J mice.

Methods: Acute UC model was induced in mice using 2% DSS. Fecal samples were collected from the mice on days 0, 4, and 7 post-treatment for metabolomic analysis of bile acids.

INSTRUMENT(S): Liquid Chromatography MS - negative - reverse-phase

PROVIDER: MTBLS14031 | MetaboLights | 2026-05-03

REPOSITORIES: MetaboLights