Mouse Brown Adipose Tissue Lipidomics under Cold and Dietary Fat Interventions

ABSTRACT: This study investigates lipidomic remodeling in mouse brown adipose tissue under a 2 × 3 experimental design involving environmental condition and dietary fatty acid composition. Mice were maintained at room temperature with ad libitum feeding or exposed to 4°C cold conditions with 70% calorie restriction. Under each condition, mice were fed diets differing in fatty acid composition: a low-fat LM diet, a high-MUFA HM diet, or a high-SFA HS diet. Brown adipose tissue samples were analyzed by LC-MS/MS-based lipidomics to characterize diet- and cold-associated changes in lipid species, lipid classes, and lipid metabolic profiles.

INSTRUMENT(S): Liquid Chromatography MS - alternating - reverse-phase

PROVIDER: MTBLS14642 | MetaboLights | 2026-06-01

REPOSITORIES: MetaboLights