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Metabolome and exposome profiling of the biospecimens from COVID-19 patients in India (Blood plasma assay)

ABSTRACT:

INTRODUCTION: COVID-19 has become a global impediment by bringing everything to a halt starting from January 2020. India underwent the lockdown starting from 22nd March 2020 with the sudden spike in the number of COVID-19 patients in major cities and states. This study focused on how metabolites play a crucial role in SARSCoV-2 prognosis.

MATERIALS AND METHODS: Metabolome profiling of 106 plasma samples and 24 swab samples from symptomatic patients in the Indian population of the Mumbai region was done. COVID-19 positive samples were further segregated under the non-severe COVID-19 and severe COVID-19 patient cohort for both plasma and swab.

RESULTS: After analyzing the raw files, total 7,949 and 12,871 metabolites in plasma and swab were found. 11 and 35 significantly altered metabolites were found in COVID-19 positive compared to COVID-19 negative plasma and swab samples, respectively. Also, 9 and 23 significantly altered metabolites were found in severe COVID-19 positive to non-severe COVID-19 positive plasma and swab samples, respectively. The majorly affected pathways in COVID-19 patients were found to be the amino acid metabolism pathway, sphingosine metabolism pathway, and bile salt metabolism pathway.

CONCLUSION: This study facilitates identification of potential metabolite-based biomarker candidates for rapid diagnosis and prognosis for clinical applications.

Blood plasma assay is reported in the current study MTBLS2291.

Nasopharyngeal swab assay is reported in MTBLS2349.

INSTRUMENT(S): Liquid Chromatography MS - positive - reverse phase

SUBMITTER: Nirjhar Banerjee

PROVIDER: MTBLS2291 | MetaboLights | 2022-01-13

REPOSITORIES: MetaboLights

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Metabolome and exposome profiling of the biospecimens from COVID-19 patients in India (Nasopharyngeal swab assay)

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