Dataset Information
Metabolome of pig endometrium and placenta.
Ontology highlight
ABSTRACT: Neonatal mortality is mostly due to a reduced piglet maturity. An essential question for adaptation to extra-uterine environment lies in the optimization of the crosstalk between maternal and fetal genomes for a distribution of resources that allows fetuses to express healthier phenotypes at birth. The CO-LOcATION project proposes an integrative biology approach combining transcriptomics, metabolomics, lipidomics and maturity phenotypes to answer this crucial question for both research and pig production sustainability. The project will use samples from the former ANR PORCINET project, which produced pure genotypes and reciprocal crossbreed genotypes with contrasted robustness at birth. The complexity of the maturity phenotypes will be addressed by studying the trade-off between growth and survival with a focus on endometrial-placental interactions using whole-genome approaches.
INSTRUMENT(S): Nuclear Magnetic Resonance (NMR) -
PROVIDER: MTBLS3091 | MetaboLights | 2025-06-30
REPOSITORIES: MetaboLights
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 191000648-1-F759-E-b.zip | Other | |||
| 191000648-10-F460.zip | Other | |||
| 191000648-100-F625-E.zip | Other | |||
| 191000648-101-F677-E.zip | Other | |||
| 191000648-102-F607-E.zip | Other |
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Publications
Metabolomic analysis of the endometrium of Large White and Meishan pigs reveals differences in biological processes during late gestation.
BMC genomics 20251121 1
<h4>Background</h4>In pigs, genetic progress has led to an increase in perinatal mortality, mainly due to reduced piglet maturity. The end of gestation (90-110 days of gestation) plays a decisive role in the acquisition of fetal maturity. The endometrium is crucial for its acquisition as it provides nutrients to the fetus through the placenta. The aim of this study is to describe part of the metabolism of the endometrium in late pregnancy and in relation with neonatal survival. For this purpose, ...[more]
