Dataset Information

Human gut microbes impact host serum metabolome and insulin sensitivity

ABSTRACT: Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2 diabetes. Here we show how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic Danish individuals. The serum metabolome of insulin-resistant individuals is characterized by increased levels of branched-chain amino acids (BCAAs), which correlate with a gut microbiome that has an enriched biosynthetic potential for BCAAs and is deprived of genes encoding bacterial inward transporters for these amino acids. Prevotella copri and Bacteroides vulgatus are identified as the main species driving the association between biosynthesis of BCAAs and insulin resistance, and in mice we demonstrate that P. copri can induce insulin resistance, aggravate glucose intolerance and augment circulating levels of BCAAs. Our findings suggest that microbial targets may have the potential to diminish insulin resistance and reduce the incidence of common metabolic and cardiovascular disorders.

INSTRUMENT(S): GCxGC-TOFMS (LECO Pegasus 4D), UPLC-QTOFMS (Waters QTOF Premier)

SUBMITTER: Matej Oresic

PROVIDER: MTBLS351 | MetaboLights | 2017-08-31

REPOSITORIES: MetaboLights

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Human gut microbes impact host serum metabolome and insulin sensitivity.

Pedersen Helle Krogh HK Gudmundsdottir Valborg V Nielsen Henrik Bjørn HB Hyotylainen Tuulia T Nielsen Trine T Jensen Benjamin A H BA Forslund Kristoffer K Hildebrand Falk F Prifti Edi E Falony Gwen G Le Chatelier Emmanuelle E Levenez Florence F Doré Joel J Mattila Ismo I Plichta Damian R DR Pöhö Päivi P Hellgren Lars I LI Arumugam Manimozhiyan M Sunagawa Shinichi S Vieira-Silva Sara S Jørgensen Torben T Holm Jacob Bak JB Trošt Kajetan K Kristiansen Karsten K Brix Susanne S Raes Jeroen J Wang Jun J Hansen Torben T Bork Peer P Brunak Søren S Oresic Matej M Ehrlich S Dusko SD Pedersen Oluf O

Nature 20160713 7612

Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2 diabetes. Here we show how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic Danish individuals. The serum metabolome of insulin-resistant individuals is characterized by increased levels of branched-chain amino acids (BCAAs), which correlate with a gut microbiome that has an enriched biosynthetic potential for BCAAs and is deprived of genes encod ...[more]

PMID: 27409811

Publication: 1/3

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Human gut microbes impact host serum metabolome and insulin sensitivity

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Human gut microbes impact host serum metabolome and insulin sensitivity.

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