Dietary ε-polylysine effects plasma metabolites profiling in mice
Ontology highlight
ABSTRACT: Dietary ε-polylysine effects on gut microbiota and plasma metabolites profiling in mice. Owing to the effect of ε-polylysine on microorganisms and phospholipid metabolism, we aimed to establish a comprehensive overview of microbial colonization affecting plasma glycerophospholipid metabolism in C57 mice. In this study, we performed 16S rDNA analysis and metabolome analysis to systematically investigate the influence of the food additive ε-polylysine on the intestinal microflora and glycerophospholipid metabolism in C57 mice. We aimed to provide important data for the development and application of food additives to improve the safety of human food products. Plasma metabolomics is reported in the current study MTBLS4270. Liver metabolomics is reported in MTBLS4273.
INSTRUMENT(S): Liquid Chromatography MS - negative - reverse phase, Liquid Chromatography MS - positive - reverse phase
PROVIDER: MTBLS4270 | MetaboLights | 2025-04-14
REPOSITORIES: MetaboLights
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| A1.wiff | Wiff | |||
| A1.wiff.scan | Wiff | |||
| A10.wiff | Wiff | |||
| A10.wiff.scan | Wiff | |||
| A2.wiff | Wiff |
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Project description:<p>The proteomic and metabolomic differences in mice fed ε-polylysine were detected by high-throughput sequencing and screening. The effects of ε-polylysine on the proteome and metabolomics of C57 BL/6J mice were studied. DIA proteome sequencing and liquid chromatography-mass spectrometry (LC-MS) were used to compare ε-polylysine-modified mouse proteome and metabolome. In this study, we analyzed the regulatory effects of ε-polysine on glycerophospholipid metabolism, glutathione metabolism and ABC transporters pathways. The sequencing data and LC-MS/MS raw data of samples are stored in MetaboLights and ProteomeXchange databases for efficient reuse and to explore the differences in metabolism and protein expression among mice fed with different levels of ε-polylysine, aiming to screen for critical proteins and differential metabolites in valuable regulatory pathways. Mice in each group (n=20) were fed the same diet (AIN-76A) supplemented with 0 (group A), 300 (group B), 600 (group C), and 1,200 (group D) mg/kg ε-polylysine, respectively.</p><p><br></p><p><strong>Liver metabolomics</strong> is reported in the current study <a href='https://www.ebi.ac.uk/metabolights/MTBLS4273' rel='noopener noreferrer' target='_blank'><strong>MTBLS4273</strong></a>.</p><p><strong>Plasma metabolomics</strong> is reported in <a href='https://www.ebi.ac.uk/metabolights/MTBLS4270' rel='noopener noreferrer' target='_blank'><strong>MTBLS4270</strong></a>.</p>
2025-04-14 | MTBLS4273 | MetaboLights
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2020-07-14 | MSV000085747 | GNPS
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2020-07-16 | MSV000085765 | GNPS
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2020-06-26 | MSV000085632 | GNPS
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2020-07-14 | MSV000085743 | GNPS
Project description:<p>Chicken farming is critical for future food security, yet there is still a need for improving animal welfare and optimised feeding strategies. HoloFood will explore the interaction and impact of the microbiome together with the host (animal) in response to different feeding strategies already implemented commercially. Chicken farming has recently made huge efforts towards healthy, natural food production without using chemicals or antibiotics in food systems. As such natural alternatives, such as prebiotic and probiotic additives to chicken feed, have been a huge improvement. Nonetheless, the full impact of these natural alternatives and the variation in chicken growth is still poorly understood. HoloFood aims to investigate the effect and interplay between the host (chicken) - microbiome in response to different dietary additives.</p><p><br></p><p><strong>HoloFood Trial 1/2/3</strong> is reported in the current study <a href='https://www.ebi.ac.uk/metabolights/MTBLS6988' rel='noopener noreferrer' target='_blank'><strong>MTBLS6988</strong></a>.</p><p><strong>HoloFood Trial A - seaweed-dose response</strong> is reported in <a href='https://www.ebi.ac.uk/metabolights/MTBLS4381' rel='noopener noreferrer' target='_blank'><strong>MTBLS4381</strong></a>.</p><p><strong>HoloFood Trial B - blue mussel-dose response</strong> is reported in <a href='https://www.ebi.ac.uk/metabolights/MTBLS4382' rel='noopener noreferrer' target='_blank'><strong>MTBLS4382</strong></a>.</p><p><strong>HoloFood Trial C - blue mussel ensilage-dose response</strong> is reported in <a href='https://www.ebi.ac.uk/metabolights/MTBLS4384' rel='noopener noreferrer' target='_blank'><strong>MTBLS4384</strong></a>.</p><p><strong>HoloFood Trial D - fermented seaweed open water-dose</strong> response is reported in <a href='https://www.ebi.ac.uk/metabolights/MTBLS6733' rel='noopener noreferrer' target='_blank'><strong>MTBLS6733</strong></a>.</p><p><br></p><p><strong>Linked cross omic data sets:</strong></p><p>Nucleic acid data associated with this study are available in the European Nucleotide Archive (ENA): accession number <a href='https://www.ebi.ac.uk/ena/browser/view/PRJEB43192' rel='noopener noreferrer' target='_blank'>PRJEB43192</a>.</p><p>Metagenomic data associated with this study are available from MGnify under the Super Study '<a href='https://www.ebi.ac.uk/metagenomics/super-studies/holofood' rel='noopener noreferrer' target='_blank'>holofood</a>'.</p>
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2021-06-07 | MTBLS2782 | MetaboLights