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DIVA Metabolomics: Differentiating Vaccination Status Following Viral Challenge Using Metabolomic Profiles

ABSTRACT: This study employed metabolomic profiling technologies, to identify metabolites (small molecules) in blood which are found at different levels in vaccinated compared to non-vaccinated animals exposed to virus.

INSTRUMENT(S): Xevo G2 QTOF (Waters)

SUBMITTER: Darren Gray

PROVIDER: MTBLS456 | MetaboLights | 2018-07-13

REPOSITORIES: MetaboLights

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DIVA metabolomics: Differentiating vaccination status following viral challenge using metabolomic profiles.

Gray Darren W DW Welsh Michael D MD Mansoor Fawad F Doherty Simon S Chevallier Olivier P OP Elliott Christopher T CT Mooney Mark H MH

PloS one 20180405 4

Bovine Respiratory Disease (BRD) is a major source of economic loss within the agricultural industry. Vaccination against BRD-associated viruses does not offer complete immune protection and vaccine failure animals present potential routes for disease spread. Serological differentiation of infected from vaccinated animals (DIVA) is possible using antigen-deleted vaccines, but during virus outbreaks DIVA responses are masked by wild-type virus preventing accurate serodiagnosis. Previous work by t ...[more]

PMID: 29621258

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DIVA metabolomics: Differentiating vaccination status following viral challenge using metabolomic profiles.

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