Metabolomics

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Bluebell saponins: Application of metabolomics and molecular networking

ABSTRACT: Bulb, leaf, scape and flower samples of British bluebells (Hyacinthoides non-scripta) were collected regularly for one growth period. Methanolic extracts of freeze-dried and ground samples showed antitrypanosomal activity, giving more than 50% inhibition, for 20 out of 41 samples. High-resolution mass spectrometry was used in the dereplication of the methanolic extracts of the different plant parts. The results revealed differences in the chemical profile with bulb samples being distinctly different from all aerial parts. High molecular weight metabolites were more abundant in the flowers, shoots and leaves compared to smaller molecular weight ones in the bulbs. The anti-trypanosomal activity of the extracts was linked to the accumulation of high molecular weight compounds, which were matched with saponin glycosides, while triterpenoids and steroids occurred in the inactive extracts. Dereplication studies were employed to identify the significant metabolites via chemotaxonomic filters and considering their previously reported bioactivities.

OTHER RELATED OMICS DATASETS IN: PRJNA312142PRJNA312146

INSTRUMENT(S): Liquid Chromatography Tandem MS (LC-MS/MS)

PROVIDER: MTBLS797 | MetaboLights | 2019-03-19

REPOSITORIES: MetaboLights

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Application of metabolomics and molecular networking in investigating the chemical profile and antitrypanosomal activity of British bluebells (Hyacinthoides non-scripta).

Raheem Dotsha J DJ   Tawfike Ahmed F AF   Abdelmohsen Usama R UR   Edrada-Ebel RuAngelie R   Fitzsimmons-Thoss Vera V  

Scientific reports 20190222 1

Bulb, leaf, scape and flower samples of British bluebells (Hyacinthoides non-scripta) were collected regularly for one growth period. Methanolic extracts of freeze-dried and ground samples showed antitrypanosomal activity, giving more than 50% inhibition, for 20 out of 41 samples. High-resolution mass spectrometry was used in the dereplication of the methanolic extracts of the different plant parts. The results revealed differences in the chemical profile with bulb samples being distinctly diffe  ...[more]

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